They either received spring manufacturing equipment the four-drug combo through an IV every two weeks for about six months or Gemzar three times a month for six months.About 15 per cent of patients are candidates for surgery; generally their disease was detected early and has not spread widely beyond the pancreas.Side effects are common for both drugs including low blood counts, fatigue and diarrhea, and they occurred more often in folfirinox patients. Overall, almost two-thirds of folfirinox patients were still alive compared with almost half of Gemzar patients, unexpectedly good results, said Dr..The new results are "reassuring for a disease where unfortunately on average people only live several months rather than several years. The study was funded by philanthropic groups in France and Canada. Schilsky said both treatments are "pretty inexpensive" since the drugs are available as generics.

There was one death in the study in the Gemzar group.After an average three years of follow-up, almost 40 per cent of the folfirinox patients were disease-free compared with about 20 per cent who had the standard drug, Gemzar. Insurance typically covers both for metastatic cancer and gemcitabine for operable cancer, and its likely it would cover folfirinox for operable cancer if guidelines are revised and it becomes standard of care, which several experts say is expected. Thierry Conroy, the lead author and a cancer specialist at the Cancer Institute of Lorraine in Vandoeuvre-les-Nancy, France.Results were presented Monday at an American Society of Clinical Oncology conference in Chicago.Folfirinox and Gemzar are available as generics.Nearly 500 patients at 77 centres in France and Canada were enrolled in the study from spring 2012 through fall 2016.The results indicate the powerful chemotherapy treatment known as folfirinox will likely become standard of care for the minority of patients whose pancreatic cancer is diagnosed early enough to be removed by surgery, experts not involved in the study said.Chicago: Patients with pancreatic cancer that hadnt spread lived substantially longer on a four-drug combo than on a single standard cancer drug, a rare advance for a tough-to-treat disease, researchers reported Monday. Andrew Epstein, an expert at Memorial Sloan Kettering Cancer Centre in New York.

This is a new standard of care for this illness," said Dr.The outlook has been bleak for patients with pancreatic cancer , an uncommon disease for which there is no screening.Folfirinox is already standard treatment for patients whose pancreatic cancer has spread.Participants had early ductal tumors, the most common kind of pancreatic cancer. Symptoms including fatigue, weight loss and abdomen pain often dont occur until late, after the disease has spread. About half are diagnosed after the disease has spread; most die within a year of diagnosis and only about 6 per cent survive for five years. Richard Schilsky, the groups chief medical officer, called the research an "immediately practice-changing study" and said its the biggest advance for pancreatic cancer in 25 years.About 330,000 cases are diagnosed each year worldwide, including about 55,000 in the United States.